Oxygen availability and metabolic adaptations

Oxygen availability and metabolic reprogramming in cancer.

Hypoxia and dysregulated metabolism are defining features of solid tumors. How cancer cells adapt to low O2 has been illuminated by numerous studies, with "reprogrammed" metabolism being one of the most important mechanisms. This metabolic reprogramming not only promotes cancer cell plasticity, but also provides novel insights for treatment strategies. As the most studied O2 "sensor," hypoxia-i...

Metabolic Training Principles and Adaptations

Metabolic adaptations to arsenic-induced oxidative stress in Isatis cappadocica. Naser Karimi* and Zahra Souri

Arsenic is considered as one of the most important environmental contaminant elements. Some plant species can grow in arsenic contaminated soils and they are able to reduce arsenic toxicity. In this study, a hydroponic experiment was conducted on Isatis cappadocica, a newly-discovered As hyperaccumulator. Accordingly, we conducted this experiment to compare the interaction of effect of arsenic ...

Factors influencing oxygen availability.

This review gives an account of some of the factors affecting the transport of oxygen from the lungs until its final discharge in the tissues. The sequence of physiological and metabolic processes to be described may be considered collectively as the 'coarse adjust-ment' of oxygen transport. The 'fine adjustment' will be discussed in the succeeding chapter which surveys the local factors influe...

Metabolic Adaptations in Higher Animals

There is a marked increase in the liver glucose 6-phosphatase activity’ of rats fed a diet devoid of a direct source of glucose (1). Also the ingestion of a glucose-free diet containing a high level of protein or fructose causes an increase in liver fructose 1,6-diphosphatase activity in rabbits (2). I f these findings are not special cases, but are representative of a general phenomenon, infor...